About the lab:
Research Objectives: The Breast Cancer Translational Research lab is aimed at contributing
to the development of personalized medicine that tailors medical treatments to individual
patients. Moreover, we aim to identify molecular regulators and biomarkers involved in
breast cancer development, survival and invasion and to elucidate mechanisms of resistance
to therapies in breast cancer patients. To this end we embrace an integrated approach. Our
lab benefits from a direct access to clinical databases and to biological samples, including a
tissue-bank, facilitating relevant and significant translational research. The laboratory also
benefits from both, the strong clinical platform of the Breast Cancer Division and the cutting
edge technological and scientific facilities available at the medical center. The Laboratory
operates to establish close collaborations between basic research scientists,
bioinformaticians, oncologists, radiologists and pathologists from Israel and from worldwide
leading academic and medical institutes.
Grants
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Israel Cancer Research Fund (ICRF)
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Israel Cancer Association (ICA)
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Kamin- Ministry of health Collaborations
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Israel Science Foundation (ISF)
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Israel Precision Medicine Partnership (IPMP)
Main research topics:
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The SWI/SNF complex in breast cancer (ARID1a): prognostic and predictive implications
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STAT3 as a prognostic and predictor marker in breast cancer
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The breast tumor microenvironment role in cancer development, progression and
response to therapy -
Dissecting the Akt/mTOR pathway in estrogen receptor positive breast cancers
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Development novel strategies for success in breast cancer therapies
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